Production of low-avidity antibody by infants after infection with serogroup B meningococci

被引：15

作者：

Pollard, AJ ^{[1
]}

Levin, M ^{[1
]}

机构：

[1] St Marys Hosp, Imperial Coll Sch Med, Dept Paediat, London, England

来源：

LANCET | 2000年 / 356卷 / 9247期

关键词：

D O I：

10.1016/S0140-6736(00)03405-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experimental serogroup a meningococcal vaccines have induced only poor immune responses and have had little protective efficacy in children younger than 1 year of age. We used ELISA with potassium thiocyanate to compare the average avidity of antibody produced by infants with that of children order than 10 years after systemic disease. Infants produced specific antibody of lower average avidity than older children-a finding that correlates with absence of serum bactericidal activity in the serum samples of the same infants.

引用

页码：2065 / 2066

页数：2

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