Tuberculosis subunit vaccine development:: on the role of interferon-γ

被引：72

作者：

Agger, EM ^{[1
]}

Andersen, P ^{[1
]}

机构：

[1] Statens Serum Inst, Dept TB Immunol, DK-2300 Copenhagen S, Denmark

来源：

VACCINE | 2001年 / 19卷 / 17-19期

关键词：

tuberculosis; interferon-gamma; subunit vaccine;

D O I：

10.1016/S0264-410X(00)00519-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tuberculosis (TB) remains a major global health problem and subunit vaccines for the control of the disease are presently under development. This vaccine strategy requires an in vitro correlate of protection for the identification of relevant vaccine candidate antigens and for monitoring the induction of a protective cell-mediated immune response after vaccination, New studies of experimental vaccines in the mouse model of TB support interferon-gamma as a relevant marker for the induction of a protective immune response. In contrast, searching for immunodominant antigens capable of inducing strong interferon-gamma responses in PPD positive healthy or TB infected individuals may not identify all relevant candidate antigens for inclusion in a novel TB subunit vaccine. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2298 / 2302

页数：5

共 35 条

[1]

ALERSON MR, 2000, J EXP MED, V191, P551

[2] T-CELL PROLIFERATIVE RESPONSE TO ANTIGENS SECRETED BY MYCOBACTERIUM-TUBERCULOSIS [J].

ANDERSEN, P ;

ASKGAARD, D ;

LJUNGQVIST, L ;

BENTZON, MW ;

HERON, I .

INFECTION AND IMMUNITY, 1991, 59 (04) :1558-1563

[3] EFFECTIVE VACCINATION OF MICE AGAINST MYCOBACTERIUM-TUBERCULOSIS INFECTION WITH A SOLUBLE MIXTURE OF SECRETED MYCOBACTERIAL PROTEINS [J].

ANDERSEN, P .

INFECTION AND IMMUNITY, 1994, 62 (06) :2536-2544

[4]

BOMFORD R, 1980, CLIN EXP IMMUNOL, V39, P435

[5] ESAT-6 subunit vaccination against Mycobacterium tuberculosis [J].

Brandt, L ;

Elhay, M ;

Rosenkrands, I ;

Lindblad, EB ;

Andersen, P .

INFECTION AND IMMUNITY, 2000, 68 (02) :791-795

[6] EFFECT OF MONOPHOSPHORYL LIPID-A ON THE INVITRO FUNCTION OF PERITONEAL LEUKOCYTES FROM UREMIC PATIENTS ON CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS [J].

CAROZZI, S ;

SALIT, M ;

CANTALUPPI, A ;

NASINI, MG ;

BAROCCI, S ;

CANTARELLA, S ;

LAMPERI, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (08) :1748-1753

[7] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].

Cole, ST ;

Brosch, R ;

Parkhill, J ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Gordon, SV ;

Eiglmeier, K ;

Gas, S ;

Barry, CE ;

Tekaia, F ;

Badcock, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, R ;

Devlin, K ;

Feltwell, T ;

Gentles, S ;

Hamlin, N ;

Holroyd, S ;

Hornby, T ;

Jagels, K ;

Krogh, A ;

McLean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Osborne, J ;

Quail, MA ;

Rajandream, MA ;

Rogers, J ;

Rutter, S ;

Seeger, K ;

Skelton, J ;

Squares, R ;

Squares, S ;

Sulston, JE ;

Taylor, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 1998, 393 (6685) :537-+

[8]

Coler RN, 1998, J IMMUNOL, V161, P2356

[9] DISSEMINATED TUBERCULOSIS IN INTERFERON-GAMMA GENE-DISRUPTED MICE [J].

COOPER, AM ;

DALTON, DK ;

STEWART, TA ;

GRIFFIN, JP ;

RUSSELL, DG ;

ORME, IM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2243-2247

[10] Immunoprophylactic properties of 71-kDa cell wall-associated protein antigen of Mycobacterium tuberculosis H37Ra [J].

Dhiman, N ;

Khuller, GK .

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 1997, 186 (01) :45-51

← 1 2 3 4 →