The DF-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses

被引：359

作者：

Himly, M

Foster, DN

Bottoli, I

Iacovoni, JS

Vogt, PK

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[2] Univ Minnesota, Dept Anim Sci, St Paul, MN 55108 USA

来源：

VIROLOGY | 1998年 / 248卷 / 02期

关键词：

D O I：

10.1006/viro.1998.9290

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DF-1 is a continuous cell line of chicken embryo fibroblasts. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transformation on monolayers of DF-1, and avian leukosis viruses of envelope subgroups B, D, and C induce cell death and form plaques. The new cell line will greatly facilitate studies on oncogenic transformation and cell killing by avian viruses. (C) 1998 Academic Press.

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收藏

页码：295 / 304

页数：10

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