Nicotine modifies the activity of ventral tegmental area dopaminergic neurons and hippocampal GABAergic neurons

被引：46

作者：

Fisher, JL ^{[1
]}

Pidoplichko, VI ^{[1
]}

Dani, JA ^{[1
]}

机构：

[1] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 3-4期

关键词：

nicotine; dopamine; GABA; VTA; hippocampus;

D O I：

10.1016/S0928-4257(98)80012-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While trying to mimic the dose and time course of nicotine as it is obtained by a smoker, we found the following results. The initial arrival of even a low concentration of nicotine increased the firing rate of dopaminergic neurons from the ventral tegmental area (VTA) and increased the spontaneous vesicular release of GABA from hippocampal neurons. Longer exposure to nicotine caused variable, bur dramatic, desensitization of nicotinic receptors and diminished the effects of nicotine. The addictive properties of nicotine as well as its diverse effects on cognitive function could be mediated through differences in activation and desensitization of nicotinic receptors in various areas of the brain. ((C)Elsevier, Paris).

引用

页码：209 / 213

页数：5

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