Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population

被引：35

作者：

Darville, JM

Ley, BE

Roome, APCH

Foot, ABM

机构：

[1] Publ Hlth Lab, Bristol BS2 8EL, Avon, England

[2] Univ Bristol, Dept Pathol & Microbiol, Bristol, Avon, England

[3] Bristol Royal Hosp Sick Children, Dept Paediat Oncol, Bristol, Avon, England

来源：

BONE MARROW TRANSPLANTATION | 1998年 / 22卷 / 06期

关键词：

acyclovir-resistant herpes simplex virus infections; bone marrow transplantation;

D O I：

10.1038/sj.bmt.1701392

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Over a 3-month period, four patients who had received unrelated donor (UD) bone marrow transplants (BMT) presented with severe mucocutaneous herpes simplex virus (HSV)infection while receiving acyclovir (ACV) prophylaxis, Sensitivity testing of the isolates revealed three to be acyclovir-resistant and in one patient the infection was also characterised by a marked failure to respond to foscarnet (phosphonoformic acid). The emergence of ACV-resistant HSV infections in themselves is a new and challenging problem, and yet a far greater problem will become evident if these infections develop resistance to non thymidine kinase dependent therapy.

引用

收藏

页码：587 / 589

页数：3

相关论文

共 13 条

[1] ACYCLOVIR-RESISTANT HERPES-SIMPLEX VIRUS-INFECTIONS IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].

ERLICH, KS ;

MILLS, J ;

CHATIS, P ;

MERTZ, GJ ;

BUSCH, DF ;

FOLLANSBEE, SE ;

GRANT, RM ;

CRUMPACKER, CS .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (05) :293-296

[2] ACUTE AND RECURRENT INFECTION WITH HERPES-SIMPLEX VIRUS IN MOUSE - MODEL FOR STUDYING LATENCY AND RECURRENT DISEASE [J].

HILL, TJ ;

FIELD, HJ ;

BLYTH, WA .

JOURNAL OF GENERAL VIROLOGY, 1975, 28 (SEP) :341-353

[3] A NET +1 FRAMESHIFT PERMITS SYNTHESIS OF THYMIDINE KINASE FROM A DRUG-RESISTANT HERPES-SIMPLEX VIRUS MUTANT [J].

HWANG, CBC ;

HORSBURGH, B ;

PELOSI, E ;

ROBERTS, S ;

DIGARD, P ;

COEN, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5461-5465

[4]

NUGIER F, 1992, J MED VIROL, V67, P2501

[5]

Reusser P, 1996, BONE MARROW TRANSPL, V17, P813

[6] FOSCARNET-RESISTANT HERPES-SIMPLEX VIRUS-INFECTION IN PATIENTS WITH AIDS [J].

SAFRIN, S ;

KEMMERLY, S ;

PLOTKIN, B ;

SMITH, T ;

WEISSBACH, N ;

DEVERANEZ, D ;

PHAN, LD ;

COHN, D .

JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (01) :193-196

[7] ACYCLOVIR PROPHYLAXIS OF HERPES-SIMPLEX-VIRUS INFECTIONS - A RANDOMIZED, DOUBLE-BLIND, CONTROLLED TRIAL IN BONE-MARROW-TRANSPLANT RECIPIENTS [J].

SARAL, R ;

BURNS, WH ;

LASKIN, OL ;

SANTOS, GW ;

LIETMAN, PS .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 305 (02) :63-67

[8] Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir [J].

Sasadeusz, JJ ;

Tufaro, F ;

Safrin, S ;

Schubert, K ;

Hubinette, MM ;

Cheung, PK ;

Sacks, SL .

JOURNAL OF VIROLOGY, 1997, 71 (05) :3872-3878

[9] Comprehensive quantification of herpes simplex virus latency at the single-cell level [J].

Sawtell, NM .

JOURNAL OF VIROLOGY, 1997, 71 (07) :5423-5431

[10] SUCCESSFUL TREATMENT OF PROGRESSIVE MUCOCUTANEOUS INFECTION DUE TO ACYCLOVIR-RESISTANT AND FOSCARNET-RESISTANT HERPES-SIMPLEX VIRUS WITH (S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL)CYTOSINE (HPMPC) [J].

SNOECK, R ;

ANDREI, G ;

GERARD, M ;

SILVERMAN, A ;

HEDDERMAN, A ;

BALZARINI, J ;

SADZOTDELVAUX, C ;

TRICOT, G ;

CLUMECK, N ;

DECLERCQ, E .

CLINICAL INFECTIOUS DISEASES, 1994, 18 (04) :570-578