CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa

被引：95

作者：

Laouar, A

Haridas, V

Vargas, D

Xia, ZN

Chaplin, D

van Lier, RAW

Manjunath, N ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Univ Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

[5] Acad Med Ctr, Expt Immunol Lab, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 07期

关键词：

D O I：

10.1038/ni1212

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.

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收藏

页码：698 / 706

页数：9

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