The Xenopus laevis homologue of the 64-kDa subunit of cleavage stimulation factor

被引：5

作者：

Barbaux, S

Seery, LT

Schoenberg, DR

Sellar, GC

Whitehead, AS

机构：

[1] TRINITY COLL DUBLIN,DEPT GENET,DUBLIN 2,IRELAND

[2] TRINITY COLL DUBLIN,INST BIOTECHNOL,DUBLIN 2,IRELAND

[3] UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,BETHESDA,MD 20814

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1996年 / 114卷 / 03期

基金：

英国惠康基金;

关键词：

cleavage stimulation factor; xenopus development; polyadenylation; RNA processing; RNA binding domains; phosphorylation sites; Xenopus CstF homologue;

D O I：

10.1016/0305-0491(96)00023-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cleavage stimulation factor (CstF) is composed of three subunits of 50, 64 and 77 kDa, respectively. We report here the identification of a cDNA clone from Xenopus laevis encoding a homologue of the 64-kDa subunit of human CstF. Comparative sequence analysis reveals that these two proteins are highly conserved with the exception of a unique repeat structure found in the human, but not in the X. laevis, protein. Analysis of expression of this mRNA during X. laevis tadpole development indicates a requirement for this protein throughout all stages of development.

引用

页码：313 / 315

页数：3

共 18 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2]

AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303

[3] RNA-BINDING PROTEINS AS DEVELOPMENTAL REGULATORS [J].