HLA-DR4 influences glial activity in Alzheimer's disease hippocampus

被引：9

作者：

Aisen, PS

Luddy, A

Durner, M

Reinhard, JF

Pasinetti, GM

机构：

[1] Mt Sinai Med Ctr, Dept Psychiat, New York, NY 10029 USA

[2] Mt Sinai Med Ctr, Brookdale Ctr Mol Biol, New York, NY 10029 USA

[3] Mt Sinai Med Ctr, Fishberg Res Ctr Neurobiol, New York, NY 10029 USA

[4] Glaxo Wellcome Inc, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1998年 / 161卷 / 01期

关键词：

HLA-DR; hippocampus; GFAP; astrocytes; inflammation; anti-inflammatory therapy; Alzheimer's disease;

D O I：

10.1016/S0022-510X(98)00268-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The importance of inflammatory/immune mechanisms in Alzheimer's disease is supported by evidence that the human leukocyte antigen (HLA)-DR genotype influences risk of the disease, with a protective effect associated with the HLA-DR4 allele. We investigated the influence of the HLA-DR4 allele on glial activity, assessed by quantification of glial fibrillary acidic protein (GFAP), in hippocampal tissue from subjects with Alzheimer's disease. The mean GFAP level was significantly higher in Alzheimer's disease hippocampal specimens lacking the HLA-DR4 allele compared to specimens with similar neuropathological findings that were HLA-DR4 positive. Apolipoprotein E genotype had no influence on GFAP levels. These results indicate that HLA-DR4 may exert a protective influence on Alzheimer's disease via modulation of glial activity. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

引用

页码：66 / 69

页数：4

共 24 条

[1] Aisen PS, 1997, GERONTOLOGY, V43, P143
[2] AISEN PS, 1994, AM J PSYCHIAT, V151, P1105
[3] AISEN PS, 1995, DEMENTIA, V9, P173
[4] ASSOCIATION OF APOLIPOPROTEIN-E GENOTYPE WITH BRAIN LEVELS OF APOLIPOPROTEIN-E AND APOLIPOPROTEIN J(CLUSTERIN) IN ALZHEIMER-DISEASE
BERTRAND, P
POIRIER, J
ODA, T
FINCH, CE
PASINETTI, GM
[J]. MOLECULAR BRAIN RESEARCH, 1995, 33 (01): : 174 - 178
[5] LOCALIZATION OF GLIAL FIBRILLARY ACIDIC PROTEIN IN ASTROCYTES BY IMMUNOFLUORESCENCE
BIGNAMI, A
ENG, LF
DAHL, D
UYEDA, CT
[J]. BRAIN RESEARCH, 1972, 43 (02) : 429 - &
[6] HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease
Curran, M
Middleton, D
Edwardson, J
Perry, R
McKeith, I
Morris, C
Neill, D
[J]. NEUROREPORT, 1997, 8 (06) : 1467 - 1469
[7] IMMUNOLOGICAL ASSOCIATIONS IN FAMILIAL AND NONFAMILIAL ALZHEIMER PATIENTS AND THEIR FAMILIES
FRECKER, MF
PRYSEPHILLIPS, WEM
STRONG, HR
[J]. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1994, 21 (02) : 112 - 119
[8] PHAGOCYTIC MICROGLIA RELEASE CYTOKINES AND CYTOTOXINS THAT REGULATE THE SURVIVAL OF ASTROCYTES AND NEURONS IN CULTURE
GIULIAN, D
LI, J
LEARA, B
KEENEN, C
[J]. NEUROCHEMISTRY INTERNATIONAL, 1994, 25 (03) : 227 - 233
[9] Association of HLA class II alleles in patients with juvenile myoclonic epilepsy compared with patients with other forms of adolescent-onset generalized epilepsy
Greenberg, DA
Durner, M
Shinnar, S
Resor, S
Rosenbaum, D
Klotz, I
Dicker, E
Keddache, M
Zhou, G
Yang, XP
Altstiel, L
[J]. NEUROLOGY, 1996, 47 (03) : 750 - 755
[10] JENKINSON ML, 1989, BRIT J RHEUMATOL, V28, P86

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