Propolis:: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs

被引：69

作者：

Fernandes, A ^{[1
]}

Balestrin, EC ^{[1
]}

Elaine, J ^{[1
]}

Betoni, C ^{[1
]}

Orsi, RD ^{[1
]}

da Cunha, MDRD ^{[1
]}

Montelli, AC ^{[1
]}

机构：

[1] Univ Estadual Paulista, Univ Estadual Paulista Julio de Mesquita Filho, Inst Biociencias, Dept Microbiol & Imunol, BR-1861800 Botucatu, SP, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2005年 / 100卷 / 05期

关键词：

propolis; Staphylococcus aureus; Kirby and Bauer method; E-test method; antimicrobial drugs;

D O I：

10.1590/S0074-02762005000500018

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E-Test) on 25 S. aureus strains was evaluated Petri dishes with sub-inhibitory concentrations of EEP were incubated with 13 drugs using Kirby and Bauer method and synergism between EEP and five drugs [choramphenicol (CLO), gentamicin (GEN), netilmicin (NET), tetracycline (TET), and vancomycin (VAN)] was observed. Nine drugs were assayed by the E-test method and five of them exhibited a synergism [CLO, GEN, NET, TET and clindamycin (CLI)]. The results demonstrated the synergism between EEP and antimicrobial drugs, especially those agents that interfere on bacterial protein synthesis.

引用

页码：563 / 566

页数：4

共 25 条

[1] Recent progress in pharmacological research of propolis [J].

Banskota, AH ;

Tezuka, Y ;

Kadota, S .

PHYTOTHERAPY RESEARCH, 2001, 15 (07) :561-571

[2] In vitro activity of propolis against Streptococcus pyogenes [J].

Bosio, K ;

Avanzini, C ;

D'Avolio, A ;

Ozino, O ;

Savoia, D .

LETTERS IN APPLIED MICROBIOLOGY, 2000, 31 (02) :174-177

[3] Review of the biological properties and toxicity of bee propolis (propolis) [J].

Burdock, GA .

FOOD AND CHEMICAL TOXICOLOGY, 1998, 36 (04) :347-363

[4] Propolis, an old remedy used in modem medicine [J].

Castaldo, S ;

Capasso, F .

FITOTERAPIA, 2002, 73 :S1-S6

[5]

DETOMA P, 1991, Annali di Microbiologia ed Enzimologia, V41, P231

[6]

DRAGO I, 2002, J CHEMOTHERAPY, V12, P390

[7]

Fernandes A., 2003, REV CIENCIAS FARMACE, V24, P147

[8]

Fernandes A. Jr., 1995, Journal of Venomous Animals and Toxins, V1, P63

[9]

Fernandes A. Jr, 2001, Journal of Venomous Animals and Toxins, V7, P173

[10]

FERNANDES JA, 1997, J VENOM ANIM TOXINS, V3, P287

← 1 2 3 →