A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

被引：18

作者：

Hadano, S

Nichol, K

Brinkman, RR

Nasir, J

Martindale, D

Koop, BF

Nicholson, DW

Scherer, SW

Ikeda, JE

Hayden, MR

机构：

[1] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 4H4, Canada

[2] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada

[3] Tokai Univ, Sch Med, Japan Sci & Technol Corp, Int Cooperat Res Project, Isehara, Kanagawa 2591193, Japan

[4] Univ Victoria, Dept Biol, Ctr Environm Hlth, Victoria, BC V8W 3N5, Canada

[5] Merck Frosst Ctr Therapeut Res, Dept Mol Biol & Biochem, Pointe Claire, PQ H9R 4P8, Canada

[6] Hosp Sick Children, Dept Genet, Toronto, ON M5G 1X8, Canada

[7] Tokai Univ, Inst Med Sci, Mol Med Res Ctr, Dept Mol Neurosci, Isehara, Kanagawa 2591193, Japan

来源：

GENOMICS | 1999年 / 55卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1006/geno.1998.5637

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34, We have established a yeast artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences including 13 known genes and 39 expressed sequenced tags within this YAC contig, The establishment of a YAC contig and transcript map that spans the region containing the ALSB mutation is an essential step in the identification of the ALS2 gene. (C) 1999 Academic Press.

引用

页码：106 / 112

页数：7

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