Invadopodia: At the cutting edge of tumour invasion

被引：168

作者：

Stylli, Stanley S. ^{[1
,2
]}

Kaye, Andrew H. ^{[1
,2
]}

Lock, Peter ^{[1
]}

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Cell Signaling Lab, Dept Surg, Parkville, Vic 3050, Australia

[2] Royal Melbourne Hosp, Dept Neurosurg, Parkville, Vic 3052, Australia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2008年 / 15卷 / 07期

基金：

英国医学研究理事会;

关键词：

invadopodia; glioma; invasion; podosome; extracellular matrix;

D O I：

10.1016/j.jocn.2008.03.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Invasion of tissues by malignant tumours is facilitated by tumour cell migration and degradation of extracellular matrix (ECM) barriers. Several invasive neoplasms, including head and neck squamous cell carcinoma, breast carcinoma, melanoma and glioma, contain tumour cells that can form actin-rich protrusions with ECM proteolytic activity called invadopodia. These dynamic organelle-like structures adhere to, and digest, collagens, laminins and fibronectin. Invadopodia are dependent on multiple transmembrane, cytoplasmic and secreted proteins engaged in cell adhesion, signal transduction, actin assembly, membrane regulation and ECM proteolysis. Strategies aimed at disrupting invadopodia could form the basis of novel anti-invasive therapies for treating patients. Here we review the molecular basis of invadopodia formation with particular emphasis on the intracellular signaling networks that are essential for invadopodia activity and examine the potential role of these structures in glioma invasion. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：725 / 737

页数：13

共 127 条

[1] The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells [J].