High Level of PTEN Expression Is Associated with Low-grade Liver Metastasis and Satisfactory Patient Survival in Pancreatic Cancer

被引：14

作者：

Feng, Chao ^{[1
]}

Yao, Ruoquan ^{[1
]}

Huang, Feizhou ^{[1
]}

Liu, Xunyang ^{[1
]}

Nie, Wanpin ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Dept Gen Surg, Changsha 410013, Hunan, Peoples R China

来源：

ARCHIVES OF MEDICAL RESEARCH | 2011年 / 42卷 / 07期

关键词：

Phosphatase and tensin homolog; Pancreatic cancer; Liver metastasis; NF-KAPPA-B; TUMOR-SUPPRESSOR; 3-KINASE PATHWAY; CELLS; ACTIVATION; PTEN/MMAC1; GENE; PI3K;

D O I：

10.1016/j.arcmed.2011.10.008

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Background and Aims. We investigated PTEN expression in primary pancreatic cancer and pancreatic cancer liver metastasis in order to evaluate the interrelationship between PTEN expression and clinicopathological characteristics of pancreatic cancer patients with and without liver metastasis. Methods. Eighty five primary pancreatic cancer specimens without liver metastasis were analyzed as controls. Eighty seven pancreatic cancer specimens and homologous liver metastasis specimens were investigated immunohistochemically, and the correlation between immunohitochemical findings and clinicopathological factors was investigated. Results. A strong PTEN expression was observed in 52 (61.2%) specimens from patients without liver metastasis. In contrast, only 26 (29.9%) specimens were observed in patients with liver metastasis. A strong PTEN expression was apparently associated with low-grade lymph node metastasis (p <0.05) and TNM stage (p <0.05). PTEN expression in patients without liver metastasis was apparently stronger than that with liver metastasis. In addition, among patients with liver metastasis, the 5-year survival rate was markedly higher in patients with strong PTEN expression compared to those with weak PTEN expression. Conclusions. Our results suggest that a high level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer. The diagnostic evaluation of PTEN expression may provide valuable prognostic information to aid treatment strategies for pancreatic cancer patients. (C) 2011 IMSS. Published by Elsevier Inc.

引用

页码：584 / 588

页数：5

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[2]

RETRACTED: Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer (Retracted Article) [J].