Upregulation of COX-2 and CGRP expression in resident cells of the Borna disease virus-infected brain is dependent upon inflammation

被引:33
作者
Röhrenbeck, AM
Bette, M
Hooper, DC
Nyberg, F
Eiden, LE
Dietzschold, B
Weihe, E
机构
[1] Univ Marburg, Inst Anat & Cell Biol, D-35032 Marburg, Germany
[2] Thomas Jefferson Univ, Dept Microbiol & Immunol, Ctr Neurovirol, Philadelphia, PA 19107 USA
[3] Uppsala Univ, Dept Pharmaceut Sci, Ctr Biomed, S-75105 Uppsala, Sweden
[4] NIMH, Mol Neurosci Sect, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA
关键词
Borna disease virus; cyclooxygenase; prostaglandin; calcitonin gene-related peptide; neuropeptide; neocortex; hippocampus; macrophage/microglia; endothelium; encephalitis; dexamethasone; neuroimmunology; neurotoxicity; neuroprotection;
D O I
10.1006/nbdi.1998.0225
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Infection of immunocompetent adult rats with Borna disease virus (BDV) causes severe encephalitis and neural dysfunction. The expression of COX-2 and CORP, genes previously shown to be implicated in CNS disease and peripheral inflammation, was dramatically upregulated in the cortical neurons of acutely BDV-infected rats. Neuronal COX-2 and CGRP upregulation was predominantly seen in brain areas where ED1-positive macrophages/microglia accumulated. In addition, COX-2 expression was strongly induced in brain endothelial cells and the number of COX-2 immunoreactive microglial cells was increased. In contrast, despite increased expression of viral antigens, neither COX-2 nor CGRP expression was altered in the CNS of BDV-infected rats treated with dexamethasone, or tolerant to BDV. Thus, increased CGRP and COX-2 expression in the BDV-infected brain is the result of the inflammatory response and likely to be involved in the pathogenesis of virus-induced encephalitis. (C) Press Academic Press.
引用
收藏
页码:15 / 34
页数:20
相关论文
共 100 条
[1]   EFFECT OF NEUROTROPIC VIRUS-INFECTION ON NEURONAL AND INDUCIBLE NITRIC-OXIDE SYNTHASE ACTIVITY IN RAT-BRAIN [J].
AKAIKE, T ;
WEIHE, E ;
SCHAEFER, M ;
FU, ZF ;
ZHENG, YM ;
VOGEL, W ;
SCHMIDT, H ;
KOPROWSKI, H ;
DIETZSCHOLD, B .
JOURNAL OF NEUROVIROLOGY, 1995, 1 (01) :118-125
[2]   Stimulation by nerve growth factor of neuropeptide synthesis in the adult rat in vivo: Bilateral response to unilateral intraplantar injections [J].
Amann, R ;
Sirinathsinghji, DJS ;
Donnerer, J ;
Liebmann, I ;
Schuligoi, R .
NEUROSCIENCE LETTERS, 1996, 203 (03) :171-174
[3]   EXPRESSION BRAIN OF A MESSENGER-RNA ENCODING A NOVEL NEUROPEPTIDE HOMOLOGOUS TO CALCITONIN GENE-RELATED PEPTIDE [J].
AMARA, SG ;
ARRIZA, JL ;
LEFF, SE ;
SWANSON, LW ;
EVANS, RM ;
ROSENFELD, MG .
SCIENCE, 1985, 229 (4718) :1094-1097
[4]   THE KINETICS AND MORPHOLOGICAL-CHARACTERISTICS OF THE MACROPHAGE MICROGLIAL RESPONSE TO KAINIC ACID-INDUCED NEURONAL DEGENERATION [J].
ANDERSSON, PB ;
PERRY, VH ;
GORDON, S .
NEUROSCIENCE, 1991, 42 (01) :201-214
[5]   PHAGOCYTIC-ACTIVITY OF MACROPHAGES AND MICROGLIAL CELLS DURING THE COURSE OF ACUTE AND CHRONIC RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS [J].
BAUER, J ;
SMINIA, T ;
WOUTERLOOD, FG ;
DIJKSTRA, CD .
JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 38 (04) :365-375
[6]   Expression and regulation of cyclooxygenase-2 in rat microglia [J].
Bauer, MKA ;
Lieb, K ;
SchulzeOsthoff, K ;
Berger, M ;
GebickeHaerter, PJ ;
Bauer, J ;
Fiebich, BL .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 243 (03) :726-731
[7]   MEDIATORS OF INJURY IN NEUROTRAUMA - INTRACELLULAR SIGNAL-TRANSDUCTION AND GENE-EXPRESSION [J].
BAZAN, NG ;
DETURCO, EBR ;
ALLAN, G .
JOURNAL OF NEUROTRAUMA, 1995, 12 (05) :791-814
[8]   UP-REGULATION OF THE MACROPHAGE SCAVENGER RECEPTOR IN RESPONSE TO DIFFERENT FORMS OF INJURY IN THE CNS [J].
BELL, MD ;
LOPEZGONZALEZ, R ;
LAWSON, L ;
HUGHES, D ;
FRASER, I ;
GORDON, S ;
PERRY, VH .
JOURNAL OF NEUROCYTOLOGY, 1994, 23 (10) :605-613
[9]   CALCITONIN GENE-RELATED PEPTIDE IS A POTENT VASODILATOR [J].
BRAIN, SD ;
WILLIAMS, TJ ;
TIPPINS, JR ;
MORRIS, HR ;
MACINTYRE, I .
NATURE, 1985, 313 (5997) :54-56
[10]   CHARACTERIZATION OF INDUCIBLE CYCLOOXYGENASE IN RAT-BRAIN [J].
BREDER, CD ;
DEWITT, D ;
KRAIG, RP .
JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 355 (02) :296-315