The microbial pan-genome

被引：873

作者：

Medini, D

Donati, C

Tettelin, H

Masignani, V

Rappuoli, R

机构：

[1] Chiron Vaccines, IRIS, I-53100 Siena, Italy

[2] Inst Genom Res TIGR, Dept Microbial Genom, Rockville, MD 20850 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.gde.2005.09.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A decade after the beginning of the genomic era, the question of how genomics can describe a bacterial species has not been fully addressed. Experimental data have shown that in some species new genes are discovered even after sequencing the genomes of several strains. Mathematical modeling predicts that new genes will be discovered even after sequencing hundreds of genomes per species. Therefore, a bacterial species can be described by its pan-genome, which is composed of a 'core genome' containing genes present in all strains, and a 'dispensable genome' containing genes present in two or more strains and genes unique to single strains. Given that the number of unique genes is vast, the pan-genome of a bacterial species might be orders of magnitude larger than any single genome.

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收藏

页码：589 / 594

页数：6

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