Patterning an epidermal field:: Drosophila Lozenge, a member of the AML-1/Runt family of transcription factors, specifies olfactory sense organ type in a dose-dependent manner

被引:42
作者
Gupta, BP
Flores, GV
Banerjee, U
Rodrigues, V
机构
[1] Tata Inst Fundamental Res, Dept Sci Biol, Mumbai, India
[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90024 USA
关键词
lozenge; olfactory sense organ; cell fate specification; antenna; runt;
D O I
10.1006/dbio.1998.9064
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sense organ development in the Drosophila antenna is initiated by the selection of a founder cell from an epidermal held. This cell is believed to recruit neighbours to form a cluster of cells which then divides to form a mature sense organ. In most systems so far studied, sense organ type appears to be specified by the identity of proneural genes involved ill the selection of precursors. The regulation of proneural gene expression is, in turn, controlled by the prepatterning genes. In the antenna, the only known proneural function is that of atonal, a gene that is involved in founder cell choice in the sensilla coeloconica, and no prepatterning gene function has yet been demonstrated. In this study, we show that Lozenge, a protein which possesses a DNA binding domain similar to that of the Acute myeloid leultemia-1/Runt transcription factors, functions in a dose-dependent manner to specify the fate of the other two types of sense organs in the antenna: the sensilla trichoidea and the sensilla basiconica. Our results suggest that Lozenge may act on the epidermal held, resulting in founder cells acquiring specific cell fates that lead to the development of an appropriate type of sense organ, (C) 1998 Academic Press.
引用
收藏
页码:400 / 411
页数:12
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