TNFα production by CD4+ T cells predicts long-term increase in lesion load on MRI in MS

被引：21

作者：

Killestein, J

Kalkers, NF

Meilof, JF

Barkhof, F

van Lier, RAW

Polman, CH

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, MS MRI Ctr, NL-1007 MB Amsterdam, Netherlands

[3] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Immunobiol, Amsterdam, Netherlands

来源：

NEUROLOGY | 2001年 / 57卷 / 06期

关键词：

D O I：

10.1212/WNL.57.6.1129

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Reliable laboratory prognostic factors for MS are still lacking. The predictive value of markers of T-cell activation for long-term disease progression was investigated. Flow cytometry measurements were correlated to changes in Expanded Disability Status Scale and MR T2 lesion load over 36 months in 14 patients with secondary progressive MS, A correlation was found between the percentage of tumor necrosis factor-a-producing CD4(+) T cells at baseline and the change in T2 lesion load during 3-year follow-up (r = 0.79, adjusted r(2) = 0.59, p = 0.001).

引用

页码：1129 / 1131

页数：3

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