Galanin modulates 5-hydroxytryptamine functions focus on galanin and galanin fragment 5-hydroxytryptamine1A receptor interactions in the brain

被引：56

作者：

Fuxe, K ^{[1
]}

Jansson, A ^{[1
]}

Diaz-Cabiale, Z ^{[1
]}

Andersson, A ^{[1
]}

Tinner, B ^{[1
]}

Finnman, UB ^{[1
]}

Misane, I ^{[1
]}

Razani, H ^{[1
]}

Wang, FH ^{[1
]}

Agnati, LF ^{[1
]}

Ögren, SO ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

来源：

GALANIN: BASIC RESEARCH DISCOVERIES AND THERAPEUTIC IMPLICATIONS | 1998年 / 863卷

关键词：

D O I：

10.1111/j.1749-6632.1998.tb10702.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reciprocal interactions between galanin and 5-HT(1A) receptors in the rat brain are presented. Galanin and its NH(2)-terminal fragments antagonize 5-HT(1A) receptor-mediated transmission at the postjunctional level, whereas galanin receptor activation mimics the inhibitory action of 5-HT(1A) receptor activation at the soma-dendritic level. leading to reductions of 5-HT metabolism and release. These interactions have been shown in both receptor binding studies and functional studies, In view of the present findings, galanin antagonists may represent a new type of antidepressant drug, based on the 5-HT hypothesis of depression, by enhancing 5-HT release and postjunctional 5-HT(1A)-mediated transmission. Moreover, following intracerebroventricular injection galanin was found to be internalized In a population of hippocampal nerve cells mainly representing GABA, somatostatin, and/or NPY-immunoreactive nerve cells. The relevance of these findings is discussed in relation to the concept of volume transmission.

引用

页码：274 / 290

页数：17

共 38 条

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