Evidence for regulation of vasopressin gene transcription by the NMDA receptor

被引：6

作者：

Amaya, F

Hayashi, S

Tanaka, M

Tanaka, Y

Ibata, Y ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kamigyo Ku, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Dept Anesthesiol, Kamigyo Ku, Kyoto 6028566, Japan

来源：

NEUROREPORT | 1999年 / 10卷 / 01期

关键词：

arginine vasopressin; dizocilpine maleate; gene transcription; heterogeneous nuclear RNA; osmotic stimulation; rats; supraoptic nucleus;

D O I：

10.1097/00001756-199901180-00030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE investigated the effects of dizocilpine maleate (MK-801), an NMDA receptor antagonist, on arginine vasopressin heterogeneous nuclear RNA expression in the supraoptic nucleus in the rat hypothalamus. MK-801 treatment completely blocked the osmotic stimulus-induced increase in AVP hnRNA expression, but had no effect on basal AVP hnRNA expression in the SON. These observations indicate that the NMDA receptor is essential for regulation of AVP gene transcription in response to osmotic stimulation, but has no effect on steady-state AVP gene transcription. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：157 / 160

页数：4

共 19 条

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