Aging Biology and Novel Targets for Drug Discovery

被引：44

作者：

Le Couteur, David G. ^{[1
,2
]}

McLachlan, Andrew J. ^{[1
,3
]}

Quinn, Ronald J. ^{[4
]}

Simpson, Stephen J. ^{[5
]}

de Cabo, Rafael ^{[6
]}

机构：

[1] Univ Sydney, Ctr Educ & Res Ageing, Concord Hosp, Sydney, NSW 2006, Australia

[2] Univ Sydney, ANZAC Res Inst, Concord Hosp, Sydney, NSW 2006, Australia

[3] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia

[4] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[5] Univ Sydney, Sch Biol Sci, Sydney, NSW 2006, Australia

[6] NIA, Lab Expt Gerontol, Baltimore, MD 21224 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2012年 / 67卷 / 02期

基金：

英国医学研究理事会;

关键词：

GENETICALLY HETEROGENEOUS MICE; CALORIE RESTRICTION MIMETICS; SMALL-MOLECULE ACTIVATORS; EXTENDING LIFE-SPAN; GROWTH-HORMONE; OXIDATIVE STRESS; SACCHAROMYCES-CEREVISIAE; CLINICAL-PHARMACOLOGY; DIETARY RESTRICTION; RETARDED GROWTH;

D O I：

10.1093/gerona/glr095

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Despite remarkable technological advances in genetics and drug screening, the discovery of new pharmacotherapies has slowed and new approaches to drug development are needed. Research into the biology of aging is generating many novel targets for drug development that may delay all age-related diseases and be used long term by the entire population. Drugs that successfully delay the aging process will clearly become "blockbusters." To date, the most promising leads have come from studies of the cellular pathways mediating the longevity effects of caloric restriction (CR), particularly target of rapamycin and the sirtuins. Similar research into pathways governing other hormetic responses that influence aging is likely to yield even more targets. As aging becomes a more attractive target for drug development, there will be increasing demand to develop biomarkers of aging as surrogate outcomes for the testing of the effects of new agents on the aging process.

引用

页码：168 / 174

页数：7

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