Genome-Wide Association Study of Pancreatic Cancer in Japanese Population

被引：117

作者：

Low, Siew-Kee ^{[1
,2
]}

Kuchiba, Aya ^{[3
]}

Zembutsu, Hitoshi ^{[1
]}

Saito, Akira ^{[3
,6
]}

Takahashi, Atsushi ^{[4
]}

Kubo, Michiaki ^{[5
]}

Daigo, Yataro ^{[1
,2
]}

Kamatani, Naoyuki ^{[4
]}

Chiku, Suenori ^{[3
,7
]}

Totsuka, Hirohiko ^{[3
,8
]}

Ohnami, Sumiko ^{[3
]}

Hirose, Hiroshi ^{[9
]}

Shimada, Kazuaki ^{[10
]}

Okusaka, Takuji ^{[11
]}

Yoshida, Teruhiko ^{[3
]}

Nakamura, Yusuke ^{[1
]}

Sakamoto, Hiromi ^{[3
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan

[2] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Tokyo, Japan

[3] Natl Canc Ctr, Res Inst, Div Genet, Tokyo 104, Japan

[4] RIKEN, Ctr Genom Med, Lab Stat Anal, Tokyo, Japan

[5] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Kanagawa, Japan

[6] StaGen Co Ltd, Stat Genet Anal Div, Tokyo, Japan

[7] Mizuho Informat & Res Inst Inc, Sci Solut Div, Tokyo, Japan

[8] Hitachi Govt & Publ Corp Syst Engn Ltd, Ctr Res & Dev, Bioinfomat Grp, Tokyo, Japan

[9] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan

[10] Natl Canc Ctr, Hepatobiliary & Pancreat Surg Div, Tokyo, Japan

[11] Natl Canc Ctr, Hepatobiliary & Pancreat Oncol Div, Tokyo, Japan

来源：

PLOS ONE | 2010年 / 5卷 / 07期

关键词：

AFFECT TELOMERE LENGTH; TUMOR-SUPPRESSOR GENE; DUCTAL ADENOCARCINOMA; RISK; SUSCEPTIBILITY; MUTATIONS; CARCINOMA; RELATIVES; VARIANTS; YEAST;

D O I：

10.1371/journal.pone.0011824

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value, 5 x 10(-7)) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30 x 10(-7), 3.30 x 10(-7), and 4.41 x 10(-7); located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.

引用

页数：7

共 40 条

[1]

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer [J].

Amundadottir, Laufey ;

Kraft, Peter ;

Stolzenberg-Solomon, Rachael Z. ;

Fuchs, Charles S. ;

Petersen, Gloria M. ;

Arslan, Alan A. ;

Bueno-de-Mesquita, H. Bas ;

Gross, Myron ;

Helzlsouer, Kathy ;

Jacobs, Eric J. ;

LaCroix, Andrea ;

Zheng, Wei ;

Albanes, Demetrius ;

Bamlet, William ;

Berg, Christine D. ;

Berrino, Franco ;

Bingham, Sheila ;

Buring, Julie E. ;

Bracci, Paige M. ;

Canzian, Federico ;

Clavel-Chapelon, Francoise ;

Clipp, Sandra ;

Cotterchio, Michelle ;

de Andrade, Mariza ;

Duell, Eric J. ;

Fox, John W., Jr. ;

Gallinger, Steven ;

Gaziano, J. Michael ;

Giovannucci, Edward L. ;

Goggins, Michael ;

Gonzalez, Carlos A. ;

Hallmans, Goran ;

Hankinson, Susan E. ;

Hassan, Manal ;

Holly, Elizabeth A. ;

Hunter, David J. ;

Hutchinson, Amy ;

Jackson, Rebecca ;

Jacobs, Kevin B. ;

Jenab, Mazda ;

Kaaks, Rudolf ;

Klein, Alison P. ;

Kooperberg, Charles ;

Kurtz, Robert C. ;

Li, Donghui ;

Lynch, Shannon M. ;

Mandelson, Margaret ;

McWilliams, Robert R. ;

Mendelsohn, Julie B. ;

Michaud, Dominique S. .

NATURE GENETICS, 2009, 41 (09) :986-U47

[2]

Anderson K., 2006, Cancer of the Pancreas, P721

[3]

A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length [J].

Askree, SH ;

Yehuda, T ;

Smolikov, S ;

Gurevich, R ;

Hawk, J ;

Coker, C ;

Krauskopf, A ;

Kupiec, M ;

McEachern, MJM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (23) :8658-8663

[4]

ABNORMALITIES OF THE P53 TUMOR SUPPRESSOR GENE IN HUMAN PANCREATIC-CANCER [J].

BARTON, CM ;

STADDON, SL ;

HUGHES, CM ;

HALL, PA ;

OSULLIVAN, C ;

KLOPPEL, G ;

THEIS, B ;

RUSSELL, RCG ;

NEOPTOLEMOS, J ;

WILLIAMSON, RCN ;

LANE, DP ;

LEMOINE, NR .

BRITISH JOURNAL OF CANCER, 1991, 64 (06) :1076-1082

[5]

COMPARATIVE-ANALYSIS OF MUTATIONS IN THE P53 AND K-RAS GENES IN PANCREATIC-CANCER [J].

BERROZPE, G ;

SCHAEFFER, J ;

PEINADO, MA ;

REAL, FX ;

PERUCHO, M .

INTERNATIONAL JOURNAL OF CANCER, 1994, 58 (02) :185-191

[6]

Real-time quantitative PCR of telomerase mRNA is useful for the differentiation of benign and malignant pancreatic disorders [J].

Büchler, P ;

Conejo-Garcia, JR ;

Lehmann, G ;

Müller, T ;

Emrich, T ;

Reber, HA ;

Büchler, MW ;

Friess, H .

PANCREAS, 2001, 22 (04) :331-340

[7]

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[8]

FREQUENT SOMATIC MUTATIONS AND HOMOZYGOUS DELETIONS OF THE P16 (MTS1) GENE IN PANCREATIC ADENOCARCINOMA [J].

CALDAS, C ;

HAHN, SA ;

DACOSTA, LT ;

REDSTON, MS ;

SCHUTTE, M ;

SEYMOUR, AB ;

WEINSTEIN, CL ;

HRUBAN, RH ;

YEO, CJ ;

KERN, SE .

NATURE GENETICS, 1994, 8 (01) :27-32

[9]

Identification of novel highly expressed genes in pancreatic ductal adenocarcinornas through a Bioinformatics analysis of expressed sequence tags [J].

Cao, DF ;

Hustinx, SR ;

Sui, GP ;

Bala, P ;

Sato, N ;

Martin, S ;

Maitra, A ;

Murphy, KM ;

Cameron, JL ;

Yeo, CJ ;

Kern, SE ;

Goggins, M ;

Pandey, A ;

Hruban, RH .

CANCER BIOLOGY & THERAPY, 2004, 3 (11) :1081-1089

[10]

Long-term follow-up of patients with clinically indeterminate suspicion of pancreatic cancer and normal EUS [J].

Catanzaro, A ;

Richardson, S ;

Veloso, H ;

Isenberg, GA ;

Wong, RCK ;

Sivak, MV ;

Chak, A .

GASTROINTESTINAL ENDOSCOPY, 2003, 58 (06) :836-840

← 1 2 3 4 →