New chaps in the histone chaperone arena

被引:34
作者
Campos, Eric I. [1 ]
Reinberg, Danny [1 ]
机构
[1] NYU, Sch Med, Dept Biochem, Howard Hughes Med Inst, New York, NY 10016 USA
基金
加拿大自然科学与工程研究理事会;
关键词
Histone variant; H3.3; histone chaperone; PML-NBs; ASSEMBLY PATHWAY; DNA-REPLICATION; VARIANT H3.3; LYSINE; 9; CHROMATIN; PROTEIN; ASF1; DAXX; REGIONS; NUCLEOSOMES;
D O I
10.1101/gad.1946810
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drane and colleagues (pp. 1253-1265) identified DAXX as a novel H3.3-specific chaperone. This finding, in the context of others published by Goldberg and colleauges in Cell and Sawatsubashi and colleagues (pp. 159-170) in the January 15, 2010, issue of Genes & Development, provides the impetus for uncovering the mechanistic and functional properties of alternative histone deposition pathways.
引用
收藏
页码:1334 / 1338
页数:5
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