Potential roles of insulin and IGF-1 in Alzheimer's disease

被引：224

作者：

Gasparini, L

Xu, HX

机构：

[1] Nicox Res Inst, I-20091 Milan, Italy

[2] Rockefeller Univ, Fisher Ctr Res Alzheimer Dis, New York, NY 10021 USA

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 08期

关键词：

D O I：

10.1016/S0166-2236(03)00163-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling by insulin and insulin-like-growth-factor 1 (IGF-1) with Alzheimer's disease (AD). Recent compelling biological data reveal effects of insulin and IGF-1 on molecular and cellular mechanisms underlying the pathology of AD. This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD.

引用

页码：404 / 406

页数：3

共 27 条

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