Curdlan-mediated regulation of human phagocyte-specific chitotriosidase

被引：16

作者：

van Eijk, Marco ^{[1
]}

Voorn-Brouwer, Tineke ^{[1
]}

Scheij, Saskia S. ^{[1
]}

Verhoeven, Arthur J. ^{[1
]}

Boot, Rolf G. ^{[1
]}

Aerts, Johannes M. F. G. ^{[1
]}

机构：

[1] Univ Amsterdam, Dept Med Biochem, Acad Med Ctr, NL-1100 DE Amsterdam, Netherlands

来源：

FEBS LETTERS | 2010年 / 584卷 / 14期

关键词：

Monocyte/macrophage; Neutrophils; Chitinase; Chitotriosidase; Phagocyte; ACIDIC MAMMALIAN CHITINASE; INFLAMMATION; THERAPY;

D O I：

10.1016/j.febslet.2010.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human phagocyte-specific chitotriosidase is part of innate immunity and shows anti-fungal activity towards chitin-containing fungi. We investigated the effect of stimulation of the C-type lectin receptor dectin-1 by beta-1,3-glucan (curdlan) on chitotriosidase expression and release by human phagocytes. We observed that curdlan triggers chitotriosidase release from human neutrophils. In addition, we show that curdlan impairs chitotriosidase induction in monocytes. Finally, curdlan temporarily induces chitotriosidase in enzyme-expressing monocyte-derived macrophages, followed by reduction of chitotriosidase expression after prolonged stimulation. These data on regulation of phagocyte-specific chitotriosidase following curdlan recognition support an important role of chitotriosidase in the elimination of chitin-containing pathogens. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3165 / 3169

页数：5

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