γ-SECRETASE AND THE INTRAMEMBRANE PROTEOLYSIS OF NOTCH

被引：41

作者：

Jorissen, Ellen ^{[1
,2
]}

De Strooper, Bart ^{[1
,2
]}

机构：

[1] VIB, KULeuven, Ctr Human Genet, Louvain, Belgium

[2] VIB, Dept Mol & Dev Genet, Louvain, Belgium

来源：

NOTCH SIGNALING | 2010年 / 92卷

关键词：

AMYLOID PRECURSOR PROTEIN; FAMILIAL ALZHEIMERS-DISEASE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SIGNALING PATHWAY; INTRACELLULAR DOMAIN; TRANSMEMBRANE DOMAIN; BETA-PROTEIN; WILD-TYPE; PRESENILIN/GAMMA-SECRETASE; NUCLEAR TRANSLOCATION;

D O I：

10.1016/S0070-2153(10)92006-1

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

gamma-secretase is the crucial proteolytic activity that releases the Notch intracellular domain and is therefore a central player in the canonical Notch-signaling transduction pathway. We discuss here briefly the discovery of gamma-secretase and what is known on its structure and function. Recent work also indicates that the assembly and activity of gamma-secretase might be regulated by novel cell biological mechanisms. Finally we explore the recent insight that there are several gamma-secretase complexes in mammalian and discuss possibilities to use gamma-secretase as a drug target in Alzheimer's disease and cancer.

引用

页码：201 / 230

页数：30

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