Synthesis of optically active α-aminobenzolactam via an oxidative-cyclization reaction

被引：17

作者：

Chang, CY ^{[1
]}

Yang, TK ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 14期

关键词：

D O I：

10.1016/S0957-4166(03)00408-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A convergent pathway for the asymmetric synthesis of (-)-alpha-aminobenzolactam I is described. For the first time, the key intermediate N-methoxybenzolactam 8 was prepared from L-homophenylalanine ethyl ester hydrochloride (LHPE.HCl) 5 by employing an oxidative cyclization in the presence of trifluoroacetic acid (TFA). (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2081 / 2085

页数：5

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