Fission yeast Csk1 is a CAK-activating kinase (CAKAK)

被引:49
作者
Hermand, D
Pihlak, A
Westerling, T
Damagnez, V
Vandenhaute, J
Cottarel, G
Mäkelä, TP
机构
[1] Univ Helsinki, Haartman Inst, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Biocentrum Helsinki, FIN-00014 Helsinki, Finland
[3] Univ Namur, Lab Genet Mol, FUNDP, GEMO, B-5000 Namur, Belgium
[4] Mitotix Inc, Cambridge, MA 02139 USA
关键词
CAK; CAKAK; Csk1; Mcs2; Mcs6;
D O I
10.1093/emboj/17.24.7230
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs), For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK), Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).
引用
收藏
页码:7230 / 7238
页数:9
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