Role of angiotensin III in hypertension

被引：32

作者：

Reaux-Le Goazigo, A ^{[1
]}

Iturrioz, X ^{[1
]}

Fassot, C ^{[1
]}

Claperon, C ^{[1
]}

Roques, BP ^{[1
]}

Llorens-Cortes, C ^{[1
]}

机构：

[1] Coll France, INSERM, U691, F-75231 Paris, France

来源：

CURRENT HYPERTENSION REPORTS | 2005年 / 7卷 / 02期

关键词：

D O I：

10.1007/s11906-005-0087-z

中图分类号：

R6 [外科学];

学科分类号：

1002 [临床医学]; 100210 [外科学];

摘要：

The hyperactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several types of experimental and genetic hypertension animal models. Among the main bioactive pepticles of the brain RAS, angiotensin (Ang) II and Ang III display the same affinity for type I and type 2 Ang II receptors. Both peptides, injected intracereb roventricularly, similarly increase blood pressure (BP); however, because Ang II is converted in vivo to Ang III, the identity of the true effector is unknown. In this article, we review new insights into the predominant role of brain Ang III in the control of BP, underlining the fact that brain aminopeptidase A (APA), the enzyme-forming central Ang III, could constitute a putative central therapeutic target for the treatment of hypertension. This justifies the development of potent systemically active APA inhibitors, such as RB150, as prototypes of a new class of anti hypertensive agents for the treatment of certain forms of hypertension.

引用

页码：128 / 134

页数：7

共 60 条

[1]

ABHOLD RH, 1987, J PHARMACOL EXP THER, V242, P957

[2]

AHMAD S, 1990, J PHARMACOL EXP THER, V252, P643

[3]

[Anonymous], 1992, HDB CHEM NEUROANATOM

[4]

Role of area postrema in transgene hypertension [J].