Synthesis and bioactivities of steroid derivatives as antifungal agents

被引：30

作者：

Chung, SK ^{[1
]}

Ryoo, CH

Yang, HW

Shim, JY

Kang, MG

Lee, KW

Kang, HI

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

[2] Yuhan Res Ctr, Gunpo 435030, Kyunggi Do, South Korea

来源：

TETRAHEDRON | 1998年 / 54卷 / 52期

关键词：

D O I：

10.1016/S0040-4020(98)01000-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of lanosterol and cholesterol derivatives with modified side chain structures, which might interfere with sterol C24-methyltransferase in the ergosterol biosynthesis as substrate analogs, have been synthesized. The in vitro bioassay studies have shown that some of these compounds, in particular with C24-amino- and thio-functionalities, possess potent antifungal activities. in vivo. Bioassays have also been carried out for the leading compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：15899 / 15914

页数：16

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