6-Thioguanine: A naked bullet? (or how pharmacogenomics can make old drugs brand new)

被引:10
作者
Baert, F [1 ]
Rutgeerts, P [1 ]
机构
[1] Univ Hosp Gasthuisberg, Dept Internal Med, B-3000 Louvain, Belgium
关键词
D O I
10.1097/00054725-200108000-00002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:190 / 191
页数:2
相关论文
共 10 条
[1]   Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy [J].
Colombel, JF ;
Ferrari, N ;
Debuysere, H ;
Marteau, P ;
Gendre, JP ;
Bonaz, B ;
Soulé, JC ;
Modgliani, R ;
Touze, Y ;
Catala, P ;
Libersa, C ;
Broly, F .
GASTROENTEROLOGY, 2000, 118 (06) :1025-1030
[2]   Enhanced bioavailability of azathioprine compared to 6-mercaptopurine therapy in inflammatory bowel disease: correlation with treatment efficacy [J].
Cuffari, C ;
Hunt, S ;
Bayless, TM .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2000, 14 (08) :1009-1014
[3]   Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease [J].
Dubinsky, MC ;
Lamothe, S ;
Yang, HY ;
Targan, SR ;
Sinnett, D ;
Théorêt, Y ;
Seidman, EG .
GASTROENTEROLOGY, 2000, 118 (04) :705-713
[4]   An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy [J].
Dubinsky, MC ;
Hassard, PV ;
Seidman, EG ;
Kam, LY ;
Abreu, MT ;
Targan, SR ;
Vasiliauskas, EA .
INFLAMMATORY BOWEL DISEASES, 2001, 7 (03) :181-189
[5]  
DUBINSKY MC, 2000, GASTROENTEROLOGY, V118, pA4926
[6]   Variable correlation between 6-mercaptopurine metabolites in erythrocytes and hematologic toxicity: Implications for drug monitoring in children with acute lymphoblastic leukemia [J].
Innocenti, F ;
Danesi, R ;
Favre, C ;
Nardi, M ;
Menconi, MC ;
Di Paolo, A ;
Bocci, G ;
Fogli, S ;
Barbara, C ;
Barachini, S ;
Casazza, G ;
Macchia, P ;
Del Tacca, M .
THERAPEUTIC DRUG MONITORING, 2000, 22 (04) :375-382
[7]   Azathioprine for maintenance of remission in Crohn's disease: Benefits outweigh the risk of lymphoma [J].
Lewis, JD ;
Schwartz, JS ;
Lichtenstein, GR .
GASTROENTEROLOGY, 2000, 118 (06) :1018-1024
[8]  
RELLING MV, 1999, J NATL CANCER I, V91, P1983
[9]  
Thomsen JB, 1999, CANCER-AM CANCER SOC, V86, P1080, DOI 10.1002/(SICI)1097-0142(19990915)86:6<1080::AID-CNCR26>3.0.CO
[10]  
2-5