Iridal-type triterpenoids with ichthyotoxic activity from Belamcanda chinensis

被引：54

作者：

Ito, H ^{[1
]}

Onoue, S ^{[1
]}

Miyake, Y ^{[1
]}

Yoshida, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np980271b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ichthyotoxic activity-guided fractionation of the hexane and ether extracts of Belamcanda chinensis (Iridaceae) has resulted in the isolation of eleven iridal-type triterpenoids including six new compounds, 3-O-tetradecanoyl-16-O-acetylisoiridogermanal (4), 3-O-decanoyl-16-O-acetylisoiridogermanal (5), belachinal (7), anhydrobelachinal (9), epianhydrobelachinal (10), and isoanhydrobelachinal (11). Structures of the new iridals were determined by spectral and chemical methods. The absolute configuration of isoiridogermanal (1) at C-16 was determined to be R by the modified Mosher's method. Of these compounds, 16-O-acetylisoiridogermanal (3), 7, and spiroiridal (12) exhibited potent ichthyotoxic activity against killiefish (Oryzias Latipes).

引用

页码：89 / 93

页数：5

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