Low plasma stem cell factor levels correlate with in vitro leukemic growth in myelodysplastic syndromes

被引：8

作者：

Cortelezzi, A ^{[1
]}

Cattaneo, C ^{[1
]}

Cristiani, S ^{[1
]}

Sarina, B ^{[1
]}

Pomati, M ^{[1
]}

Silvestris, I ^{[1
]}

Ibatici, A ^{[1
]}

Maiolo, AT ^{[1
]}

机构：

[1] Osped Maggiore, IRCCS, Inst Serv Ematol, I-20122 Milan, Italy

来源：

LEUKEMIA RESEARCH | 1999年 / 23卷 / 03期

关键词：

stem cell factor; c-kit; myelodysplastic syndromes; clonogenic assay;

D O I：

10.1016/S0145-2126(98)00175-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/cluster ratio. No correlation was found between BM plasma SCF levels, the pattern of growth and CD34(+) c-kit(+) expression. These data seem to exclude any direct effect of SCF on leukemogenesis, but suggest that low plasma SCF levels may be at least partially responsible for leukemic growth in MDS. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：271 / 275

页数：5

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