Chromosome instability induced in the cell progeny of human T lymphocytes irradiated in G0 with γ-rays

被引：8

作者：

Bortoletto, E

Mognato, M

Ferraro, P

Canova, S

Cherubini, R

Celotti, L

Russo, A

机构：

[1] Univ Padua, Dept Biol, I-35020 Padua, Italy

[2] Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Padua, Italy

来源：

MUTAGENESIS | 2001年 / 16卷 / 06期

关键词：

D O I：

10.1093/mutage/16.6.529

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report the occurrence of chromosome instability in human T lymphocytes irradiated in vitro with gamma -rays and cultured for several generations before analysis. The delayed effects of gamma -radiation have been evaluated by conventional and molecular (chromosome painting) cytogenetics in preparations obtained from long-term bulk cultures or clonal cultures. The results indicate that the cell progeny of gamma irradiated human T lymphocytes can be characterized by a higher rate of chromosome damage, but this effect depends on the individual donor response to ionizing radiation. Evidence has been collected about a differential involvement of chromosomes 7, 9 and 19 in the induced chromosome rearrangements, and this effect is equally visible as an immediate or delayed response of human T lymphocytes to ionizing radiation.

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页码：529 / 537

页数：9

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