Interferon, a growing cytokine family: 50 years of interferon research

被引：86

作者：

Chelbi-Alix, Mounira K.

Wietzerbin, Juana

机构：

[1] Inst Lwoff, CNRS, FRE2944, F-94801 Villejuif, France

[2] Inst Curie, U653, F-75005 Paris, France

来源：

BIOCHIMIE | 2007年 / 89卷 / 6-7期

关键词：

IFN; signaling; dsRNA; IFN therapy; DOUBLE-STRANDED-RNA; NF-KAPPA-B; CONSTITUTIVE EXPRESSION; ANTIVIRAL DEFENSE; ADAPTER PROTEIN; HERPES-SIMPLEX; CROSS-TALK; VIRUS; GAMMA; INFECTION;

D O I：

10.1016/j.biochi.2007.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The establishment of an antiviral state in cells is the defining activity of interferons (IFNs) as well as the property that permitted their discovery in 1957 by Isaacs and Lindenmann. In addition, interferons have other cellular functions that have potential clinical applications. Today, interferons are used for the treatment of a variety of malignancies and viral diseases. The publication of this special issue of Biochimie gives us a great opportunity to review the state of the art in knowledge about interferons and to explore possible future directions. This commentary text will introduce the reviews written by colleagues who are experts in different aspects of interferon research, to mark the 50th anniversary of the discovery of interferon. (C) 2007 Elsevier Masson SAS. All rights reserved.

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页码：713 / 718

页数：6

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