Sesquiterpene lactones from Centaurea thessala and Centaruea attica.: Antifungal activity

被引：87

作者：

Skaltsa, H ^{[1
]}

Lazari, D

Panagouleas, C

Georgiadou, E

Garcia, B

Sokovic, M

机构：

[1] Univ Athens, Sch Pharm, Dept Pharmacognosy, GR-15771 Athens, Greece

[2] Univ Valencia, Fac Chem, Dept Organ Chem, E-46100 Valencia, Spain

[3] Inst Biol Res, Mycol Lab, Dept Plant Physiol, YU-11000 Belgrade, Yugoslavia

来源：

PHYTOCHEMISTRY | 2000年 / 55卷 / 08期

关键词：

Centaurea thessala ssp drakiensis; Centaurea attica ssp attica; Asteraceae; sesquiterpene lactones; germacranolides; elemanolides; eudesmanolides; eudesmane derivative; antifungal activity;

D O I：

10.1016/S0031-9422(00)00254-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：903 / 908

页数：6

共 39 条

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