Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues

被引：126

作者：

Moskovitz, J ^{[1
]}

Jenkins, NA ^{[1
]}

Gilbert, DJ ^{[1
]}

Copeland, NG ^{[1
]}

Jursky, F ^{[1
]}

Weissbach, H ^{[1
]}

Brot, N ^{[1
]}

机构：

[1] NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, FREDERICK, MD 21702 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 08期

关键词：

D O I：

10.1073/pnas.93.8.3205

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Peptide methionine sulfoxide reductase (MsrA; EC 1.8.4.6) is a ubiquitous protein that can reduce methionine sulfoxide residues in proteins as well as in a large number of methyl sulfoxide compounds, The expression of MsrA in various rat tissues was determined by using immunocytochemical staining. Although the protein was found in all tissues examined, it,vas specifically localized to renal medulla and retinal pigmented epithelial cells, and it was prominent in neurons and throughout the nervous system. In addition, blood and alveolar macrophages showed high expression of the enzyme, The msrA gene was mapped to the central region of mouse chromosome 14, in a region of homology with human chromosomes 13 and 8p21.

引用

页码：3205 / 3208

页数：4

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