Differences of μ-opioid receptors between Lewis and F344 rats

被引：14

作者：

Herradón, G ^{[1
]}

Morales, L ^{[1
]}

Alguacil, LF ^{[1
]}

机构：

[1] San Pablo CEU Univ, Pharmacol Lab, Madrid 28668, Spain

来源：

LIFE SCIENCES | 2003年 / 73卷 / 12期

关键词：

Lewis; Fischer; 344; DAMGO; mu-opioid receptor;

D O I：

10.1016/S0024-3205(03)00479-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

F344 and Lewis rats show different responses to opioids in several experimental paradigms. In this study we have used the specific mu-opioid agonist DAMGO to find out if these differences could be attributed to heterogeneity of mu-opioid receptors. The density of [H-3]DAMGO binding sites was similar in the brain cortex and spinal cord of both strains, but DAMGO affinity for mu-opioid receptors was higher in F344 tissues. Moreover, a parallel study of the effects of DAMGO on electrically-evoked twitches of isolated vasa deferentia revealed that this drug was also more effective in F344 preparations. These results suggest that mu-opioid receptors of F344 rats are more sensitive to pharmacological stimulation in vitro, which could be related to a higher drug affinity. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：1537 / 1542

页数：6

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