Asymmetric synthesis of the mC7N core of the manumycin family:: Preparation of (+)-MT35214 and a formal total synthesis of (-)-alisamycin

被引：63

作者：

Macdonald, G

Alcaraz, L

Lewis, NJ

Taylor, RJK ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England

[2] SmithKline Beecham Pharmaceut, Tonbridge TN11 9AN, Kent, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 30期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(98)01047-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric approach to the mC(7)N epoxyquinone central unit of the manumycin antibiotics is described based on the enantioselective (89% ee) chiral phase transfer epoxidation of a substituted cyclohexenone. The chiral epoxide is employed in the first syntheses of the tide compounds in enantiomerically pure form. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5433 / 5436

页数：4

共 31 条

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