Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central nervous system: therapeutic potential in neurological diseases

被引：47

作者：

Figueiredo, Claudia P. ^{[1
,3
]}

Pamplona, Fabricio A. ^{[2
,3
]}

Mazzuco, Tania L. ^{[6
]}

Aguiar, Aderbal S., Jr. ^{[2
]}

Walz, Roger ^{[3
,4
,5
]}

Schroeder Prediger, Rui Daniel ^{[2
,3
]}

机构：

[1] Univ Fed Santa Catarina, Univ Hosp, Dept Ciencias Fisiol, Programa Posgrad Neurociencias, BR-88049900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Univ Hosp, Ctr Ciencias Biol, Dept Farmacol, BR-88049900 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Univ Hosp, Ctr Neurociencias Aplicadas, BR-88049900 Florianopolis, SC, Brazil

[4] Univ Fed Santa Catarina, Univ Hosp, Dept Clin Med, BR-88049900 Florianopolis, SC, Brazil

[5] Hosp Governador Celso Ramos, Ctr Epilepsia Santa Catarina, Florianopolis, SC, Brazil

[6] Univ Estadual Londrina, Univ Hosp, Dept Clin Med, Serv Endocrinol, Londrina, Parana, Brazil

来源：

BEHAVIOURAL PHARMACOLOGY | 2010年 / 21卷 / 5-6期

关键词：

Alzheimer's disease; animal models; central nervous system; GIP receptor; glucose-dependent insulinotropic polypeptide; mesial temporal lobe epilepsy related to hippocampal sclerosis; neurological diseases; neuroplasticity; Parkinson's disease; GASTRIC-INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE-1; TEMPORAL-LOBE EPILEPSY; ADULT MAMMALIAN BRAIN; FACILITATE HIPPOCAMPAL LTP; CELLULAR PRION PROTEIN; IN-SITU HYBRIDIZATION; AMYLOID-BETA-PROTEIN; NEURAL STEM-CELLS; PARKINSONS-DISEASE;

D O I：

10.1097/FBP.0b013e32833c8544

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone, secreted from the enteroendocrine K cells, which has insulin-releasing and extra-pancreatic actions. GIP and its receptor present a widespread distribution in the mammalian brain where they have been implicated with synaptic plasticity, neurogenesis, neuroprotection and behavioral alterations. This review attempts to provide a comprehensive picture of the role of GIP in the central nervous system and to highlight recent findings from our group showing its potential involvement in neurological illnesses including epilepsies, Parkinson's disease and Alzheimer's disease. Behavioural Pharmacology 21:394-408 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：394 / 408

页数：15

共 131 条

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