Blood transfers infectious immunologic tolerance in MHC-incompatible heart transplantation in rats

被引：6

作者：

Bektas, H ^{[1
]}

Schrem, H ^{[1
]}

Lehner, F ^{[1
]}

Lueck, R ^{[1
]}

Becker, T ^{[1
]}

Musholt, T ^{[1
]}

Klempnauer, J ^{[1
]}

机构：

[1] Hannover Med Sch, Viszeral & Transplantat Chirurg Klin, D-30623 Hannover, Germany

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2005年 / 24卷 / 05期

关键词：

D O I：

10.1016/j.healun.2004.01.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Infectious tolerance or inducing immunologic tolerance of infection in allografts is still poorly understood. We investigated whether transfusing blood from LEW. 1A rats tolerant of LEW. 1W hearts could transmit tolerance to naive LEW. 1A rats. In 4 of 6 cases, transfusing blood from tolerant animals was followed by immunologic tolerance of heart transplants from LEW. 1W donor rats in LEW. 1A recipient animals, whereas transplanting heart grafts that were tolerated in previous transplantations across MHC barriers did not transfer tolerance in major histocompatibility complex (MHC)-incompatible animals. We conclude that in rat heart transplantation, the transfer of immunologic tolerance can be enhanced by transfusing blood from tolerant animals to naive animals before transplantation across MHC barriers. Copyright (c) 2005 by the International Society for Heart and Lung Transplantation.

引用

页码：614 / 617

页数：4

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