Lactate stress test in the diagnosis of mitochondrial myopathy

被引:33
作者
Finsterer, J
Shorny, S
Capek, J
Cerny-Zacharias, C
Pelzl, B
Messner, R
Bittner, RE
Mamoli, B
机构
[1] Univ Vienna, Inst Anat, Neuromuscular Dept, Vienna, Austria
[2] Ludwig Boltzman Inst Res Neuromuscular Disorders, Vienna, Austria
关键词
venous lactate; mitochondrial myopathies; bicycle ergometer; exercise stress test;
D O I
10.1016/S0022-510X(98)00170-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of the study was to determine the sensitivity and specificity of the lactate stress test in the detection of mitochondrial myopathies. Thirty one healthy subjects, 10 patients with non-mitochondrial myopathy and 26 patients with mitochondrial myopathy underwent lactate stress testing at a standardized workload of 30 W during 15 min on a bicycle ergometer. Lactate was determined before the exercise (R1), 5, 10, 15 min after starting the exercise (S5, S10, S15) and 15 min after finishing the exercise (R2). A result was interpreted as pathologic if more than two of the five lactate values were above the corresponding upper reference limits. The upper reference limits for the venous lactate at R1; S5, S10, S15 and R2 were 1.9, 2.0, 2.1, 2.0 and 1.7 mmol/l respectively. The lactate stress test was pathologic 1/10 of the non;mitochondrial myopathies and in 18/26 of the mitochondrial myopathies. The sensitivity of the lactate stress test was 69%. The specificity of the test was 90%. in conclusion, the lactate stress test proved to be helpful for evaluating the integrity of the oxidative metabolism in the majority of patients with mitochondrial myopathy. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:176 / 180
页数:5
相关论文
共 14 条
[1]   MITOCHONDRIAL MYOPATHIES [J].
DIMAURO, S ;
BONILLA, E ;
ZEVIANI, M ;
NAKAGAWA, M ;
DEVIVO, DC .
ANNALS OF NEUROLOGY, 1985, 17 (06) :521-538
[2]  
HALLER RG, 1994, MYOLOGY, P807
[3]   A PARTIAL DEFICIENCY OF CYTOCHROME-C OXIDASE IN CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA [J].
JOHNSON, MA ;
TURNBULL, DM ;
DICK, DJ ;
SHERRATT, HSA .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1983, 60 (01) :31-53
[4]   CHILDHOOD MITOCHONDRIAL MYOPATHY WITH OPHTHALMOPLEGIA [J].
LAND, JM ;
HOCKADAY, JM ;
HUGHES, JT ;
ROSS, BD .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1981, 51 (03) :371-382
[5]   MITOCHONDRIAL MYOPATHY CHARACTERIZED BY A DEFICIENCY IN REDUCIBLE CYTOCHROME-B [J].
MORGANHUGHES, JA ;
DARVENIZA, P ;
KAHN, SN ;
LANDON, DN ;
SHERRATT, RM ;
LAND, JM ;
CLARK, JB .
BRAIN, 1977, 100 (DEC) :617-640
[6]  
MORGANHUGHES JA, 1994, MYOLOGY, P1610
[7]   IMPROVEMENT OF ABNORMAL PYRUVATE METABOLISM AND CARDIAC CONDUCTION DEFECT WITH COENZYME-Q10 IN KEARNS-SAYRE SYNDROME [J].
OGASAHARA, S ;
YORIFUJI, S ;
NISHIKAWA, Y ;
TAKAHASHI, M ;
WADA, K ;
HAZAMA, T ;
NAKAMURA, Y ;
HASHIMOTO, S ;
KONO, N ;
TARUI, S .
NEUROLOGY, 1985, 35 (03) :372-377
[8]   THE CLINICAL-FEATURES OF MITOCHONDRIAL MYOPATHY [J].
PETTY, RKH ;
HARDING, AE ;
MORGANHUGHES, JA .
BRAIN, 1986, 109 :915-938
[9]  
SHAPIRA AHV, 1994, MITOCHONDRIAL DISORD, P75
[10]   FAMILIAL POLIODYSTROPHY, MITOCHONDRIAL MYOPATHY, AND LACTATE ACIDEMIA [J].
SHAPIRA, Y ;
CEDERBAUM, SD ;
CANCILLA, PA ;
NIELSEN, D ;
LIPPE, BM .
NEUROLOGY, 1975, 25 (07) :614-621