The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans

被引：71

作者：

Menzel, Stephan

Jiang, Jie

Silver, Nicholas

Gallagher, Joy

Cunningham, Juliette

Surdulescu, Gabriela

Lathrop, Mark

Farrall, Martin

Spector, Tim D.

Thein, Swee Lay

机构：

[1] Kings Coll London, Sch Med, Dept Haematol Med, James Black Ctr,Div Gene & Cell Based Therapy, London SE5 9NU, England

[2] Kings Coll London, Sch Med, Div Gen & Mol Med, London, England

[3] Ctr Natl Genotypage, Inst Genom, Commissariat & Energie Atom, Evry, France

[4] Wellcome Trust Ctr Human Genet, Oxford, England

来源：

BLOOD | 2007年 / 110卷 / 10期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1182/blood-2007-05-093419

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIPvariability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.

引用

页码：3624 / 3626

页数：3

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