Microwave-assisted synthesis of bioactive quinazolines and quinazolinones

被引：46

作者：

Besson, Thierry ^{[1
]}

Chosson, Elizabeth ^{[1
]}

机构：

[1] Univ Rouen, INSA Rouen, CNRS UMR 6014, COBRA IRCOF,UFR Med Pharm, F-76183 Rouen 1, France

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2007年 / 10卷 / 10期

关键词：

heterocycles; quinazolines; quinazolin-4-ones; natural products; bioactive compounds; microwave irradiation; graphite; solvent-free chemistry;

D O I：

10.2174/138620707783220356

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper aims to review recent developments in the synthesis of quinazolines and quinazolinone derivatives under conditions that include the application of microwave heating in the ring forming step. Recently, two reviews on the synthesis and chemistry of natural and synthetic quinazolines and quinazolinones have been published. This review highlights significant examples where microwave heating has been either synthetically enabling or has provided a key advantage over conventional thermal methods. Wherever possible, this review will focus on chemistry carried out using mono-mode systems and well-designed type of instrumentation. The review is grouped according to the main heterocycle types in order of increasing complexity; commencing with quinazolines and their derivatives. The microwave-assisted synthesis of quinazolines and quinazolinones will be classified and based on the substitution patterns of the ring system. Syntheses of heterocyclic systems of particular biological or commercial interest are emphasized.

引用

页码：903 / 917

页数：15

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