Multiple kinases and system robustness - A link between Cdc37 and genome integrity

被引：16

作者：

Caplan, Avrom J. ^{[1
]}

Ma'ayan, Avi ^{[1
]}

Willis, Ian M. ^{[2
]}

机构：

[1] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

[2] Albert Einstein Coll Med, Dept Biochem, New York, NY USA

来源：

CELL CYCLE | 2007年 / 6卷 / 24期

关键词：

molecular chaperone; protein kinase; Cdc37; synthetitc gene array; cell cycle; genome integrity;

D O I：

10.4161/cc.6.24.5147

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

引用

页码：3145 / 3147

页数：3

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