Splicing of a rare class of introns by the U12-dependent spliceosome

被引：113

作者：

Will, CL ^{[1
]}

Lührmann, R ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany

来源：

BIOLOGICAL CHEMISTRY | 2005年 / 386卷 / 08期

关键词：

pre-mRNA splicing; U11/U12; snRNP; U12-dependent spliceosome;

D O I：

10.1515/BC.2005.084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2- or U12-dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains to be learned about the less abundant U12-type spliceosome. This review. focuses on recent advances in elucidating the structure and function of the minor U12-dependent spliceosome. Interesting similarities and differences between the U12- and U2-dependent spliceosomes are also highlighted.

引用

页码：713 / 724

页数：12

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