The Emerging Roles of Exosomes as EMT Regulators in Cancer

被引：126

作者：

Kim, Hyunwoo ^{[1
]}

Lee, Sungmin ^{[1
]}

Shin, Eunguk ^{[1
]}

Seong, Ki Moon ^{[2
]}

Jin, Young Woo ^{[2
]}

Youn, HyeSook ^{[3
]}

Youn, BuHyun ^{[1
,4
]}

机构：

[1] Pusan Natl Univ, Dept Integrated Biol Sci, Busan 46241, South Korea

[2] Korea Inst Radiol & Med Sci, Natl Radiat Emergency Med Ctr, Lab Low Dose Risk Assessment, Seoul 01812, South Korea

[3] Sejong Univ, Dept Integrat Biosci & Biotechnol, Seoul 05006, South Korea

[4] Pusan Natl Univ, Dept Biol Sci, Busan 46241, South Korea

来源：

CELLS | 2020年 / 9卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Epithelial mesenchymal transition; Exosome; Cancer; Wnt; beta-catenin pathway; Hippo pathway; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; COLORECTAL-CANCER; MIR-200; FAMILY; LUNG-CANCER; TUMOR PROGRESSION; DOWN-REGULATION; HIPPO PATHWAY; FEEDBACK LOOP; UP-REGULATION;

D O I：

10.3390/cells9040861

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Epithelial-mesenchymal transition (EMT) causes epithelial cells to lose their polarity and adhesion property, and endows them with migratory and invasive properties to enable them to become mesenchymal stem cells. EMT occurs throughout embryonic development, during wound healing, and in various pathological processes, including tumor progression. Considerable research in the last few decades has revealed that EMT is invariably related to tumor aggressiveness and metastasis. Apart from the interactions between numerous intracellular signaling pathways known to regulate EMT, extracellular modulators in the tumor microenvironment also influence tumor cells to undergo EMT, with extracellular vesicles (EVs) receiving increasing attention as EMT inducers. EVs comprise exosomes and microvesicles that carry proteins, nucleic acids, lipids, and other small molecules to stimulate EMT in cells. Among EVs, exosomes have been investigated in many studies, and their role has been found to be significant with respect to regulating intercellular communications. In this review, we summarize recent studies on exosomes and their cargoes that induce cancer-associated EMT. Furthermore, we describe the possible applications of exosomes as promising therapeutic strategies.

引用

页数：21

共 156 条

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