RecQ helicases and topoisomerases: components of a conserved complex for the regulation of genetic recombination

被引：35

作者：

Wu, L ^{[1
]}

Hickson, ID ^{[1
]}

机构：

[1] Univ Oxford, Weatherall Inst Mol Med, Imperial Canc Res Fund Labs, John Radcliffe Hosp, Oxford OX3 9DS, England

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2001年 / 58卷 / 07期

关键词：

RecQ helicases; topoisomerase; Bloom's syndrome; Werner's syndrome; genetic recombination; genomic instability;

D O I：

10.1007/PL00000909

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maintenance of genomic stability relies on the efficient and accurate execution of DNA repair pathways, and is essential for cell viability and the prevention of cancer. Mutation of genes encoding RecQ helicases or topoisomerases gives rise to genomic instability through excessive recombination. Here, we review the recent biochemical and genetic evidence to indicate that these two classes of protein act in concert in a conserved pathway to maintain genomic stability by preventing inappropriate recombination.

引用

页码：894 / 901

页数：8

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