Effects of Atorvastatin on Pathological Changes in Brain Tissue and Plasma MMP-9 in Rats with Intracerebral Hemorrhage

被引：48

作者：

Cui, Jing-Jing ^{[1
]}

Wang, Dong ^{[1
]}

Gao, Fei ^{[1
]}

Li, Yue-Rong ^{[1
]}

机构：

[1] Binzhou Med Coll, Affiliated Hosp, Dept Cardiovasol, Binzhou 256600, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 62卷 / 01期

关键词：

Atorvastatin; Intracerebral hemorrhage; Hydrocephalus; MMP-9; TYPE-2; DIABETES-MELLITUS; MARKERS;

D O I：

10.1007/s12013-011-9264-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (MMP-9) after intracerebral hemorrhage (ICH) in rats. A rat model of ICH was established by intracerebral injection of collagenase. The brain water content was determined by the wet/dry weight ratio, ultrastructural changes in brain tissue were observed by electron microscopy, and the level of plasma MMP-9 was quantified by ELISA. Atorvastatin showed significant effects in reducing the brain water content, blocking neuron apoptosis, and decreasing plasma MMP-9 in rats with ICH. There was a positive linear correlation between plasma MMP-9 and the brain water content. Atorvastatin can significantly relieve brain edema, decrease the brain injury caused by MMP-9 and protect neurons in rats with ICH.

引用

页码：87 / 90

页数：4

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