Corticotropin-releasing factor binding protein - A ligand trap?

被引：18

作者：

Jahn, O ^{[1
]}

Radulovic, J ^{[1
]}

Stiedl, O ^{[1
]}

Tezval, H ^{[1
]}

Eckart, K ^{[1
]}

Spiess, J ^{[1
]}

机构：

[1] Max Planck Inst Expt Med, Dept Mol Neuroendocrinol, D-37075 Gottingen, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 10期

关键词：

corticotropin-releasing factor (CRF); CRF binding protein (CRFBP); CRFBP inhibitor; urocortin; cognitive deficits;

D O I：

10.2174/138955705774329500

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

引用

页码：953 / 960

页数：8

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