Nonspecific modification of cellular immunity by Yersinia enterocolitica

被引:5
作者
RuizBravo, A
JimenezValera, M
Roman, SM
机构
[1] Departamento de Microbiología, Fac. de Farmacia (Campus de Cartuja), Universidad de Granada, 18071, Granada
关键词
Yersinia enterocolitica; immunomodulation; cellular immunity;
D O I
10.1016/0165-2478(95)02481-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An isogenic pair of virulent and avirulent Yersinia enterocolitica O9 strains was used to examine the influence of the virulence plasmid on the non-specific modification of the cellular immunity in BALB/c mice after experimental infection with yersiniae. The modification of contact hypersensitivity response to dinitrofluorobenzene, resistance to the syngeneic lymphoma LSTRA, and resistance to Listeria monocytogenes was heavily influenced by the presence of the virulence plasmid. As a general rule for the modification of cellular immunity by yersiniae, the plasmid-bearing strain induced a short-term suppression followed by a potentiation, whereas the isogenic plasmid-less derivative induced only a short-term potentiation. The Yersinia-mediated enhancement of cellular immunity resulted in protection against infection with Listeria and partial protection against LSTRA transplantation. Results of Concanavalin A-induced proliferation of splenocytes from Yersinia-infected mice suggested a role for cytokines as gamma-interferon in the Yersinia-mediated immunopotentiation.
引用
收藏
页码:57 / 61
页数:5
相关论文
共 23 条
[1]   THE CELL BIOLOGY OF MACROPHAGE ACTIVATION [J].
ADAMS, DO ;
HAMILTON, TA .
ANNUAL REVIEW OF IMMUNOLOGY, 1984, 2 :283-318
[2]   IMMUNE-RESPONSES TO YERSINIA-ENTEROCOLITICA IN SUSCEPTIBLE BALB/C AND RESISTANT C57BL/6 MICE - AN ESSENTIAL ROLE FOR GAMMA-INTERFERON [J].
AUTENRIETH, IB ;
BEER, M ;
BOHN, E ;
KAUFMANN, SHE ;
HEESEMANN, J .
INFECTION AND IMMUNITY, 1994, 62 (06) :2590-2599
[3]   FACTORS PROMOTING ACUTE AND CHRONIC DISEASES CAUSED BY YERSINIAE [J].
BRUBAKER, RR .
CLINICAL MICROBIOLOGY REVIEWS, 1991, 4 (03) :309-324
[4]   ROLES OF GAMMA-INTERFERON AND OTHER CYTOKINES IN SUPPRESSION OF THE SPLEEN-CELL PROLIFERATIVE RESPONSE TO CONCANAVALIN-A AND TOXOPLASMA ANTIGEN DURING ACUTE TOXOPLASMOSIS [J].
CANDOLFI, E ;
HUNTER, CA ;
REMINGTON, JS .
INFECTION AND IMMUNITY, 1995, 63 (03) :751-756
[5]  
CORNELIS G, 1987, REV INFECT DIS, V9, P64
[6]  
DUBEY DP, 1986, MANUAL CLIN LABORATO, P847
[7]  
JOHNSON AG, IMMUNOMODULATION BAC, P1
[8]   EFFECTIVE PROTECTION AGAINST LISTERIA-MONOCYTOGENES AND DELAYED-TYPE HYPERSENSITIVITY TO LISTERIAL ANTIGENS DEPEND ON COOPERATION BETWEEN SPECIFIC L3T4+ AND LYT 2+ T-CELLS [J].
KAUFMANN, SHE ;
HUG, E ;
VATH, U ;
MULLER, I .
INFECTION AND IMMUNITY, 1985, 48 (01) :263-266
[9]   SELECTIVE ANERGY OF V-BETA-8+,CD4+ T-CELLS IN STAPHYLOCOCCUS ENTEROTOXIN B-PRIMED MICE [J].
KAWABE, Y ;
OCHI, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (04) :1065-1070
[10]   PLASMID-MEDIATED RESISTANCE TO PHAGOCYTOSIS IN YERSINIA-ENTEROCOLITICA [J].
LIAN, CJ ;
HWANG, WS ;
PAI, CH .
INFECTION AND IMMUNITY, 1987, 55 (05) :1176-1183