Genital Tract Inflammation During Early HIV-1 Infection Predicts Higher Plasma Viral Load Set Point in Women

被引：60

作者：

Roberts, Lindi

Passmore, Jo-Ann S. ^{[1
,2
]}

Mlisana, Koleka ^{[3
]}

Williamson, Carolyn ^{[3
]}

Little, Francesca ^{[4
]}

Bebell, Lisa M. ^{[3
,5
]}

Walzl, Gerhard ^{[6
]}

Abrahams, Melissa-Rose

Woodman, Zenda ^{[7
]}

Karim, Quarraisha Abdool ^{[3
,5
]}

Karim, Salim S. Abdool ^{[3
,5
]}

机构：

[1] Univ Cape Town, Sch Med, Inst Infect Dis & Mol Med, Div Med Virol, ZA-7925 Cape Town, South Africa

[2] Natl Hlth Lab Serv, Cape Town, South Africa

[3] Univ KwaZulu Natal, Nelson Mandela Sch Med, Ctr AIDS Programme Res S Africa, Durban, South Africa

[4] Univ Cape Town, Dept Stat Sci, ZA-7925 Cape Town, South Africa

[5] Columbia Univ, Dept Epidemiol, New York, NY USA

[6] Univ Stellenbosch, Sch Med, Fac Hlth Sci, ZA-7505 Tygerberg, South Africa

[7] Univ Cape Town, Dept Mol & Cell Biol, ZA-7925 Cape Town, South Africa

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED-DISEASES; T-CELL RESPONSES; CERVICOVAGINAL SECRETIONS; VAGINAL TRANSMISSION; RHESUS MACAQUES; ACTIVATION; SIV; CYTOKINES; IMPACT;

D O I：

10.1093/infdis/jir715

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Methods. Inflammatory cytokine concentrations were measured in cervicovaginal lavage (CVL) from 49 women 6, 17, 30, and 55 weeks after HIV-1 infection and from 22 of these women before infection. Associations between genital inflammation and viral load set point and blood CD4 cell counts 12 months after infection were investigated. Results. Elevated genital cytokine concentrations 6 and 17 weeks after HIV-1 infection were associated with higher viral load set points and, to a lesser extent, with CD4 depletion. CVL cytokine concentrations during early infection did not differ relative to preinfection but were elevated in women who had vaginal discharge, detectable HIV-1 RNA in their genital tracts, and lower blood CD4 counts. Conclusion. Genital inflammation during early HIV-1 infection was associated with higher viral load set point and CD4 depletion, which are markers of rapid disease progression. Strategies aimed at reducing genital inflammation during early HIV-1 infection may slow disease progression.

引用

页码：194 / 203

页数：10

共 34 条

[1]

Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection [J].